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Levothyroxine sodium

CAS No. 55-03-8

Levothyroxine sodium ( L-T4 sodium,L-Thyroxine sodium,LT4 sodium )

Catalog No. M22952 CAS No. 55-03-8

Levothyroxine, the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Levothyroxine sodium
  • Note
    Research use only, not for human use.
  • Brief Description
    Levothyroxine, the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR.
  • Description
    Levothyroxine, the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR.
  • Synonyms
    L-T4 sodium,L-Thyroxine sodium,LT4 sodium
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Thyroid Hormone
  • Research Area
    Endocrine system
  • Indication
    Hypothyroidism

Chemical Information

  • CAS Number
    55-03-8
  • Formula Weight
    798.85
  • Molecular Formula
    C15H10I4NO4.Na
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/ml (125.18 mM)
  • SMILES
    N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O[Na])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mitin T, et al. Drug Metab Dispos. 2004, 32(8):779-82.
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